Building a Research Agenda for Dengue Immune Correlates
April 4, 2016 - Les Pensières, Annecy, France
At the « Summit on Dengue Immune Correlates of Protection », held at Les Pensières in Annecy, France, on March 8-9, 2016, leading dengue experts from diverse fields came together to (i) discuss the current understanding of the immune response to and protection from dengue virus infection, (ii) identify key unanswered questions, (iii) discuss potential « reporting standards » for immune correlates data and plans for comparison of results across assays/consortia, and (iv) propose a Research Agenda for investigation of dengue immune correlates.
Specific sessions focused on: definitions of immune correlates for infectious diseases and how immune correlates have been established for other diseases; the knowledge of dengue immunity and immune correlates based on cohort studies in endemic areas and vaccine trials; challenges to defining immune correlates based on our understanding of the virus and current tools for measuring immunity; the role of cell-mediated immunity in protection and pathogenesis; and recommendations based on current vaccine trial data and upcoming vaccine candidates.
The sessions were congenial and collaborative, and began with a plenary introducing the theme, presentations on key topics to spark discussion, and small working group sessions to develop consensus research priorities for the dengue community. These conclusions will be written up in a report entitled, “State-of-the-art and research agenda for correlates of immunity for dengue”.
Participants also organized standing working committees for specific projects, including development of panels of reference reagents (e.g., viruses and sera); standardization of neutralization assays; the role of cellular immunology; next-gen B cell and antibody assays; and cross-cohort comparisons that will calibrate immune measures and analysis approaches to allow direct comparison of the epidemiological context of each site.
Eva Harris PhD
Professor, Division of Infectious Diseases and Vaccinology
Director, Center for Global Public Health
UC Berkeley School of Public Health